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Exploring the World of Alt Cannabinoids: A Deep Dive into THCv

6 min readFeb 28, 2024

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Does Weederall Live Up to the Hype?

THCv is getting a lot of attention for its many health benefits.

The world of cannabis is vast and diverse, with a multitude of compounds and strains that offer unique effects and benefits. While THC and CBD have gained widespread recognition and popularity, there are other lesser-known cannabinoids that are worth exploring. One such cannabinoid is THCv, also known on the interwebs as “Weederall”, a reference to the well known ADHD medicine, Adderall.

THCv, or tetrahydrocannabivarin, is a minor cannabinoid that is found in small quantities in certain strains of cannabis. Unlike THC, THCv does not produce a psychoactive effect, at least not when studied in a lab. Many online users do report slight psychoactive effects which are probably due more to the way it is commonly sold with a small amount of Delta 8/9 for more noticeable effects. Instead, it is known for its appetite suppressant and energy-boosting properties. Some users have reported that THCv helps them to feel more focused and alert, making it a popular choice for daytime use.

One of the most intriguing aspects of THCv is its potential as a treatment for obesity and diabetes. Studies have shown that THCv can help to regulate blood sugar levels and reduce body weight. In one study, researchers found that THCv consumption led to a decrease in body weight and an improvement in insulin sensitivity in mice.

While THCv is still a relatively new and understudied cannabinoid, it has already gained a devoted following among cannabis enthusiasts. Some companies have even begun to breed strains that are specifically high in THCv, such as Doug’s Varin and Pineapple Purps.

As more research is conducted on THCv and its potential benefits, it is likely that we will see an increase in demand for this unique cannabinoid. Whether you are looking to manage your weight, boost your energy levels, or simply try something new, THCv may be worth exploring.

However, it is important to note that THCv is still a relatively rare and expensive cannabinoid. It may be difficult to find strains that are high in THCv, and those that are available may come at a premium price. Additionally, as with any cannabis product, it is important to use THCv responsibly and in moderation.

In conclusion, THCv is a fascinating and promising cannabinoid that is worth exploring for its unique effects and potential benefits. As more research is conducted and more strains become available, it is likely that THCv will become a more mainstream and widely used cannabinoid.

The THCv Molecule

All THCv is Not the Same

THCv, or tetrahydrocannabivarin, is a minor cannabinoid found in small quantities in certain strains of cannabis. It exists in two forms: Delta 8 THCv and Delta 9 THCv. These two forms have different properties and effects on the body.

Delta 8 THCv is less psychoactive than Delta 9 THCv, and it has a more relaxing and calming effect. It is also known for its appetite-suppressing properties, making it a potential aid for weight loss. Some users have reported that Delta 8 THCv helps them to feel more focused and clear-headed, without the intense psychoactive effects associated with Delta 9 THC.

Delta 9 THCv, on the other hand, is more psychoactive than Delta 8 THCv. It is known for its energetic and uplifting effects, as well as its potential to reduce anxiety and stress. Some users have reported that Delta 9 THCv helps them to feel more motivated and productive, making it a popular choice for daytime use.

One of the reasons why THCv is becoming more common is due to the increasing popularity of extracts. Hemp processors in states where Delta 9 THC is not currently legal are mining minor cannabinoids like THCv from hemp plants. This allows them to create products that are legal under federal law, while still offering unique effects and benefits.

Extracts containing THCv are becoming more widely available in the form of tinctures, edibles, and vape cartridges. These products allow users to easily control their dosage and experience the unique effects of THCv.

It is important to note that while THCv is a promising cannabinoid, more research is needed to fully understand its potential benefits and effects. As with any cannabis product, it is important to use THCv responsibly and in moderation. Additionally, it is recommended to consult with a healthcare professional before using THCv, especially if you are currently taking any medications or have any underlying health conditions.

How does THCv even work?

The human body has a complex system called the endocannabinoid system (ECS), which helps regulate various functions such as sleep, appetite, mood, and pain. The ECS has receptors throughout the body that interact with cannabinoids, which are compounds found in cannabis plants, as well as endocannabinoids, which are naturally produced by the body.

One of the primary receptors in the ECS is the CB1 receptor, which is primarily found in the brain and central nervous system. THC, the psychoactive compound in cannabis, binds to the CB1 receptor, producing the “high” associated with cannabis use. THCv, on the other hand, interacts with the CB1 receptor differently.

At low doses, THCv acts as a CB1 receptor antagonist, meaning it blocks the receptor and prevents other cannabinoids from binding to it. This is why THCv is non-psychoactive in lower doses and can even reduce the psychoactive effects of THC. However, at higher doses, THCv can act as a CB1 receptor agonist, meaning it binds to the receptor and activates it, producing psychoactive effects.

THCv also interacts with other receptors in the body, such as the GPR55 receptor, which is involved in regulating blood sugar levels and body weight. By activating the GPR55 receptor, THCv may help regulate blood sugar levels and reduce body weight, making it a potential treatment for obesity and diabetes.

Anatomy of the Cannabis Sativa Plant

In a widely cited study by Abioye et al. in 2020, they explored the potential therapeutic benefits of THCv. In rodent studies, THCV was shown to decrease appetite, increase satiety, and upregulate energy metabolism, making it a promising remedy for weight loss and obesity management. THCv also showed potential in managing type 2 diabetes by improving glycemic control and reducing fasting plasma glucose concentration. The unique properties of THCv, including neuroprotection and reduced side effects, make it a potential candidate for developing clinically useful therapies in the future.

In addition to its effects on the ECS, THCv has also been shown to interact with other systems in the body, such as the serotonin system, which is involved in regulating mood, appetite, and sleep. By activating the 5-HT1A receptor, THCv may produce an antipsychotic effect, making it a potential treatment for conditions such as schizophrenia.

Overall, while more research is needed to fully understand the effects and mechanisms of THCv, it is clear that it has potential as a treatment for a variety of conditions. Its unique interaction with the endocannabinoid system, as well as its potential to regulate blood sugar levels and reduce body weight, make it a promising cannabinoid worth exploring further.

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Darian West
Darian West

Written by Darian West

I ferret out things that interest me and then I write about them with fervor. Love me.

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